Fibroblast growth factor receptor 1 (FGFR1) as a therapeutic target in adenoid cystic carcinoma of the lacrimal gland
نویسندگان
چکیده
منابع مشابه
Adenoid cystic carcinoma of lacrimal gland.
Adenoid cystic carcinoma of the lacrimal gland is a relatively rare disease. Only two cases, a man of 61 and a woman of 54 were seen in our clinic from 1962-1981. They presented histopathology of the cribriform pattern characteristic of adenoid cystic carcinoma. The lesion in the male patient belonged to the solid type and was mainly composed of solid nests. It is emphasized that radiotherapy i...
متن کاملMetachronous Bilateral Adenoid Cystic Carcinoma of the Lacrimal Gland
1 Turkish Ministry of Health Ankara Atatürk Training and Research Hospital, Ankara Turkey 2 Turkish Ministry of Health Kayseri Education and Research Hospital, Kayseri, Turkey. 3 Başkent University Ankara Hospital, Ankara Turkey 4 Turkish Ministry of Health Dr.A.Y. Ankara Oncology Training and Research Hospital. Ankara Turkey 5 Retired Radiation Oncologist. Ankara Turkey Case Report American Jo...
متن کاملWhole Exome Sequencing of Lacrimal Gland Adenoid Cystic Carcinoma
Purpose To identify genomic mutations in lacrimal gland adenoid cystic carcinoma (LGACC) samples from patients. Methods Genomic DNA was extracted from LGACC specimens. Whole exome sequencing (exome-seq) was conducted to screen for mutations. Capillary sequencing was performed to verify mutations in genes shared by multiple samples. Luciferase assays were used to evaluate functional consequenc...
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Primary adenoid cystic carcinoma of the Bartholin gland is a rare carcinoma in female genitalia tract. In review of literature less than 100 cases have been reported. The presented case is a 44 - year - old married woman with complain of a painful mass in the vulvar area. The nodule was excised and microscopic examination revealed adenoid cystic carcinoma of Bartholin gland origin. A few months...
متن کاملFibroblast growth factor receptor-1 as a potential therapeutic target in sinonasal cancer.
BACKGROUND Despite multimodal treatment, sinonasal malignancies have an unfavorable prognosis. The purpose of this study was to elucidate if these tumors harbor amplifications of the fibroblast growth factor receptor 1 (FGFR1) gene, which has recently been identified as a potential therapeutic target in squamous cell lung cancer. METHODS One hundred twelve primary tumors (including squamous c...
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ژورنال
عنوان ژورنال: Oncotarget
سال: 2019
ISSN: 1949-2553
DOI: 10.18632/oncotarget.26558